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It plays parts in processes as diverse as growth, muscle building, metabolism, and tissue healing, and its commonly studied for all of those things
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Keloid Senescent Fibroblast Elimination & SASP Suppression (Communications Biology, 2025) FOXO4-DRI Induces p53-pS15 Nuclear Exclusion and Apoptosis in Keloid Fibroblast Models A study published in Communications Biology (Nature Publishing Group, 2025) used single-cell RNA sequencing to characterise the senescent cell landscape in keloids pathological scars with tumour-like aggressiveness
Lancet 351 (Suppl
This change of cell/tissue-specific expression was a result of a transgene containing the whole hGH gene and locus control region (LCR) in a fragment of human chromosome (Vakili et al., 2011, 2016)
