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Eli Lillys orforglipron is the furthest advanced, in late-stage clinical trials with potential FDA approval in 2026
Access and availability: As GLP-1 injections gain popularity, shortages arise when more medication is being prescribed than produced
According to FDA communications, some compounders may use salt forms of semaglutide (such as semaglutide sodium or semaglutide acetate) rather than the semaglutide base used in FDA-approved products
But tirzepatide can lower how much of the pill gets absorbed, so backup contraception is advised for 4 weeks after starting or increasing the dose (7)
It is the right starting point, the right partner for GHRH analog stacking, and the right option for any protocol where cortisol or appetite effects would be disruptive
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