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Traditional weight loss approachesdiet and exercise aloneoften prove insufficient for tamoxifen-treated patients because the medication's metabolic effects work against these efforts

So, while DPP-IVs may offer a better gastrointestinal (GI) adverse event profile than GLP-1RAs, they are generally less effective at reducing HbA 1C and have a lower potential for weight loss

However, a needed framing of this question is not whether GLP-1 medications induce SMM loss at all, but rather does greater SMM loss occur as compared to the normal degree of SMM loss that occurs with other weight loss interventions

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Mechanism and magnitude