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In trials with patients with type 2 diabetes and overweight/obesity, after 16 weeks of treatment with Danuglipron, the high-dose (120 mg twice daily) group showed an average weight loss of 4.2 kg and a reduction in HbA1c levels by 1.2% compared to the placebo group
But meanwhile, many physicians and researchers are raising concerns
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This adaptive mechanism is evident in the early stages of neurodegeneration, with increased expression of VEGF and other angiogenic mediators in response to hypoxic conditions (Zlokovic 2011)
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