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Dangerous oxidative products can be converted to H 2 O 2 and then to water by enzymatic antioxidants that are able to break down and get rid of free radicals in a multistep process in the presence of cofactors such as copper (Cu), zinc (Zn), manganese (Mn), selenium (Se), and iron (Fe)
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10.1080/15548627.2016.1187366 62 HuZ.YinY.JiangJ.YanC.WangY.WangD.et al (2022)
Reviews flag this as an unresolved question, especially in patients with current or prior cancer (Sehgal et al., Pharmaceuticals, 2025)
AW1 further drives immune regulation and angiogenesis through TLR4-mediated macrophage polarization [25]
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