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Berberine should not be taken during pregnancy or breastfeeding due to a theoretical risk of neonatal harm, including bilirubin displacement and kernicterus, a serious form of brain damage caused by severe jaundice in newborns
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The percentage of participants who met the criteria for resolution of MASH without worsening of fibrosis was 10% in the placebo group, 44% in the 5-mg tirzepatide group (difference vs
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