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Areas requiring further investigation: More controlled research is needed to define model-specific effects, long-term characterization, formulation differences, and translation boundaries between in vitro, animal, and human-context research

Glucagon receptor activation increases thermogenesis and energy expenditure primarily through hepatic and adipose tissue effects

The good news is that early evidence on oral semaglutide suggests a potential advantage here: One study showed that oral semaglutide improved blood sugar and reduced body fat while not significantly affecting muscle mass in those with type 2 diabetes

doi: 10.1186/s12974-016-0549-z 88 GaoDYuHLiBChenLLiXGuW

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