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Photothermal-triggered ECM clearance using mesoporous polydopamine nanoparticles encapsulating bromelain and the immune adjuvant R848 (M@B/R) has been developed to address this limitation (11)
The galactose-functionalized prodrug could be transformed into the parent active drug by the hydrolase activity of -gal and subsequently destroy senescent cells, overcoming the limitations of current senolytic drugs
Do we have bioavailability data?
It's important to note that these NHS commissioning criteria are more restrictive than the licensed indications, which permit use at lower BMI thresholds
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