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Tirzepatide's half-life is approximately 5 days, so the acute metabolic response occurs within 48 hours post-injection as gastric emptying slows and satiety signals intensify

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While oversights happen in IP services and third-party fee payment entities, oversights in fee payments are very rare In this situation, it is more likely that the realization that this patent was expiring in January of 2026 and Novo was not giving up much by deciding not to pay this fee. To simplify, think of Novos drugs as being protected by two locks in Canada

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