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While enteral administration offers several advantages over other routes of drug delivery in terms of convenience, promoting medication compliance, it faces several obstacles, of which the most widely recognized are inefficient absorption owing to physical barriers and an acidic microenvironment, along with degradation by proteases and the first-pass metabolism in the liver

Retinal neovascularization during investigation with IGF-1 for insulin resistance syndrome [PMID: 15672252] Laboratory literature summary: Retinal neovascularization during investigation with IGF-1 for insulin resistance syndrome