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The classical example of this was the recognition that an APAP overdose in the mouse causes the formation of a reactive metabolite, which first depletes glutathione (GSH) and then binds to sulfhydryl groups of proteins triggering cell death [79]

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(a ) GIPR IC 50 and GLP-1R EC 50 are comparable with both molecules, despite different GLP-1 analogs used

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Fridlender et al

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