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doi: 10.3389/fnagi.2025.1601602 Received 28 March 2025 Accepted 03 July 2025 Published 24 July 2025 Volume 17 - 2025 Edited by Rita Machado De Olivera, New University of Lisbon, Portugal Reviewed by Venkateswarlu Kanamarlapudi, Swansea University Medical School, United Kingdom Joon W Shim, Marshall University, United States Updates Copyright 2025 Li, Huang, Wang, Huang, Shi, Luo and Huang

The bidirectional relationship between T2DM and depression is formed due to their common pathophysiological mechanisms

Notably, two such trials with low dose NAC, 600 mg/day over 3 years demonstrated some efficacy in inhaled corticosteroid (ICS)-nave patients only ( High-dose NAC (1,200 mg/day) showed superior outcomes, improving lung volumes [Forced Vital Capacity (FVC), Residual Volume/ Total Lung Capacity (RV/TLC), Inspiratory Capacity (IC)] and exercise tolerance( 2575% ), reactance at 6 Hz, and resonant frequency over 1 year, while these declined with placebo ( The PANTHEON trial, a large double-blind RCT in GOLD defined COPD patients with severe airflow obstruction and a history of 2 COPD exacerbations in the previous year, found that NAC 600 mg BID reduced exacerbation rates in NAC group (497 acute exacerbations in 482 patients, 1.16 AcEx/pt/yr) versus placebo (641 acute exacerbations in 482 patients, 1.49 AcEx/Pt/yr), p 1 log 10 ) compared to untreated controls (67)

If all goes according to plan, Bydureon may be approved in the US by mid-2012 (for more information on Bydureon, please see the Learning Curve in diaTribe issue # 26)

Biotin, niacin, and other B vitamins are particularly important for maintaining healthy hair, skin, and nails, while vitamins C, D, and E provide immune and antioxidant support