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Large observational studies have found that GLP-1 receptor agonists are associated with a lower risk of non-candida urinary tract infections compared to SGLT2 inhibitors, with a hazard ratio of 0.91 or lower and statistical significance below 0.001
If a patient is doing well on Mounjaro or Wegovy, tolerating the medication, and on a clear path toward their goal, switching to an oral GLP-1 to chase convenience rarely makes clinical sense
Certain genetic variants affecting collagen production and vessel elasticity may predispose some individuals to more frequent or severe bruising
These central effects are enhanced by the drugs ability to delay gastric emptying
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