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It is plausible that age-related arterial stiffening plays a contributing role by stimulating myocardial stretch mechanisms that initiate myokine signaling or activation of the angiotensin II/TGF-beta and endothelin-1 pathways that result in excess extracellular matrix production [68,70-72]
doi:10.1016/j.obpill.2022.100018
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Ozempic commonly causes nausea, vomiting, and diarrhoea, particularly during dose escalation, which may lead to dehydration and acute kidney injury in susceptible individuals
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