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doi: 10.1124/pr.108.000604, 81 KlausenM
The standard dose escalation schedules in the prescribing information are starting points, not rigid requirements
However, consultation with your healthcare provider is necessary to determine if its right for you
Work with a licensed provider telehealth platforms or your bariatric team can evaluate your BMI (typically 27+ with a comorbidity, or 30+ without) and prescribe the appropriate medication and starting dose
Secondary resistance in patients who showed an initial response has actually been thought to be due to de novo mutations located on regions in smoothened to which hedgehog pathway inhibitors bind or selective clonal expansion of minority clones in the pre-treated tumor
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