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Common side effects during the adjustment period (typically the first 24 weeks): Mild nausea usually less intense than when first starting a GLP-1 medication Changes in appetite (some patients notice less appetite suppression early on at the starting 0.25 mg dose) Mild stomach discomfort, bloating, or constipation Injection site reactions Side effects that are less likely during the switch (compared to first-time GLP-1 use), but still possible: Significant vomiting less common given prior GLP-1 exposure, but possible Hypoglycemia particularly relevant for type 2 diabetes patients on insulin or sulfonylureas
Tip #2: Engage in Patient Education Understanding the mechanism of action, benefits, and potential side effects of semaglutide empowers patients to make informed decisions
Pregnant patients who have already exposed themselves to Semaglutide are suggested to report the same to Novo Nordisk
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This triggers a cascade where mitochondrial protein adducts cause oxidative stress, leading to the activation of c-jun N-terminal kinase (JNK)
