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Mitochondrial electron transport chain, ROS generation and uncoupling (Review)

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The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells

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This dual effect on both sides of the energy balance equation is why retatrutide produced the highest weight loss percentages of any single-agent trial