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The dollars barely move, though the optics are interesting in a market skeptical of PBMs
In simple terms, it means using smaller doses than the recommended starting dose, or not escalating the dosing until you reach a maintenance dose (which is the standard practice used in clinical trials)
They may need to adjust your treatment or suggest supplements to help with digestion
Sometimes 40 to 60 percent less than before
In the direct comparison of tirzepatide versus semaglutide, we observed CIs compatible with no difference and point estimates indicating a modest numeric advantage of semaglutide, if any, for reducing MACE, particularly among patients at high cardiovascular risk
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