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Phase I/II trial of a long peptide vaccine (LPV7) plus toll-like receptor (TLR) agonists with or without incomplete Freunds adjuvant (IFA) for resected high-risk melanoma
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[1] Cell Line:TRX2 -/- DT40 cells (chicken B-cell line) Concentration:1 mM Incubation Time:30 min pretreatment before 1 g/mL Doxycycline induction Result:Reduced activation of caspase-3 and caspase-9, key markers of mitochondrial apoptosis pathway, compared to untreated cells
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Glucose and insulin tolerance tests In order to assess the effects of the different pharmacotherapies on glucose tolerance, animals were subjected to an intraperitoneal glucose tolerance test (GTT) during the third week of treatment, 24 h after the last drug administration
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