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It reduces iron from the ferric to the ferrous state in the intestine to allow absorption, is involved in the transfer of iron from plasma transferrin to liver ferritin, and regulates iron distribution and storage by preventing the oxidation of tetrahydrofolate

On the other hand, transporter-mediated Asn uptake, such as that mediated by SLC6A14, has been reported to regulate inflammatory transcription through mechanisms including histone phosphorylation and to suppress the tendency toward M1-like polarization (68)

How Do Their Mechanisms Differ

Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A

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