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Polioencephalomalacia More commonly called goat polio or simply thiamine deficiency, polioencephalomalacia is a neurological disease characterized by brain swelling and tissue death the word literally means softening of the brain. Ruminants harbor beneficial bacteria and protozoa that produce Vitamin B12 (cobalamin) and Vitamin B1 (thiamine) under normal environmental conditions

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They are being investigated for a wide range of diseases, including cancer [4], metabolic disorders [5], autoimmune conditions [6], and wound healing [7, 8]