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org/10.1186/1550-2783-4-22 Bloomer, R

The multifaceted nature of GLP-1: Molecular mechanisms and signaling pathways in metabolic and neurodegenerative diseases

While possible, maintaining results after stopping GLP-1 therapy is challenging and requires intensive lifestyle modifications including 200-300 minutes of weekly exercise, consistent dietary changes, regular self-monitoring, and often ongoing behavioral support

Most patients start noticing changes in body fat, energy, and overall health within the first few weeks