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Hippocampus 22, 11881201

(2007) found that intranasally administered epithalon significantly activated neuron activity in the cerebral cortex of white rats, presenting findings that the peptide may be of interest in clinical applications for the treatment of CNS activity impairments [9]

Published preclinical studies have examined BPC-157 in relation to NO-related signaling, including experiments involving NOS inhibitors such as L-NAME and NOS substrate-related experimental designs involving L-arginine