Miyake N, Visser R, Kinoshita A, Yoshiura K, Niikawa N, Kondoh T, et al
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doi: 10.1523/JNEUROSCI.1668-22.2023, 29 DrewnowskiA
Perspective on the Rx Pipeline: Diabetes and GLP-1 Agonists Situation Summary Initial therapy for individuals with T2DM who are at high risk for CVD, heart failure (HF) and/or chronic kidney disease is metformin and a glucagon-like peptide 1 (GLP-1) or sodium glucose transporter ligand 2 (SGLT-2)
Latest Research on GLP-1: A Synthesis of Efficacy, Safety, Mechanisms, and Emerging Indications Reviewed by Shrishti, Research Reviewer Powered by Paperguide Literature Review Agent Updated on 28 Jul 2026 Abstract Latest GLP-1 research shows that glucagon-like peptide-1 receptor agonists are consistently effective for glycemic control and weight reduction, with tirzepatide generally outperforming semaglutide for both HbA1c and body-weight outcomes and without increasing serious adverse events or severe hypoglycaemia in comparative trials (Karagiannis et al., 2024), (Fras et al., 2021)