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Targeting the GIPR for obesity: to agonize or antagonize

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LC-MS/MS chromatogram of the analyte (bovine insulin, left) and internal standard (porcine insulin, right) Isotopic internal standards Stable isotope-labeled compounds share nearly identical molecular structures, chemical properties, and chromatographic and mass spectrometry behaviors with analytes

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In an accompanying comment, Professor Eberhard Standl, from the Munich Diabetes Research Group eV in Neuherberg, Germany, said the meta-analysis provided robust data that there was no cardiovascular safety issue with GLP-1 receptor agonists