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However, as the WTA pathway is non-essential, spontaneous resistance occurs relatively frequently in vitro (~1 in 10 6 cells) 87

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CD44, which serves as the primary receptor for hyaluronic acid, can influence tumor proliferation and metastasis through the STAT3/AKT/NF-B/IL-8 signaling pathways (69)

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Zheng Z, et al

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