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Introduction The importance of redox and metabolic states in regulating stem cell homeostasis has become increasingly clear in recent years (Perales-Clemente et al., 2014)

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A: Bi-Est is a compounded combination of estriol and estradiol, typically in an 80:20 ratio

However, total tyrosyl phosphorylation (Figure S5A) and ERK phosphorylation (Figure S5B) were not altered in Tamoxifen resistant cell with Sorafenib treatment, suggesting that the effect of Sorafenib on cell growth is unlikely through inhibition of RTKs or RAF