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Systematic reviews and meta-analyses have explored the impact of antidiabetic agents on vascular function, showing that GLP-1RAs significantly improve FMD compared to placebo (61, 62)

Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells

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Furthermore, research has shown that chronic lack of sleep may decrease glutathione levels

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