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It also activates calpains that proteolytically cleave structural and functional proteins, including Na + /K + ATPase, NCE, SERCA, and the RyR, thereby perpetuating Ca 2+ influx and worsening myocardial injury [106, 108]

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CHALLENGES AND ADHERENCE Despite its efficacy, CPAP adherence remains a challenge, with studies reporting 30-50% non-adherence rates

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Evens out skin tone and enhances clarity with low-irritating milky texture, revealing a luminous glass-skin finish that stays fresh and dewy all day

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