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Across subgroups, the weight change was consistently larger for SGLT2i recipients than for GLP1-RA recipients

In the NAAED Pregnancy Registry, 19.7% of topiramate-exposed newborns were SGA compared to 7.9% of newborns exposed to a reference AED and 5.4% of newborns of mothers without epilepsy and without AED exposure

The compound is classified as having extremely low toxicity, with preclinical LD50 values exceeding 5,000 mg/kg in rodent models

Mechanistically, we found that suppressing METTL3 and YTHDF2 prolongs the lifetimes of pluripotency-associated mRNAs, such as Nanog and Sox2 , during PNT