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In the brain, the highest densities of GLP-1R are found in the nucleus of the solitary tract, posterior area, interpeduncular nucleus, posterior dorsal nucleus, ventral tegmental area, hypothalamic nuclei, thalamic nuclei, nucleus accumbens, and the lateral septum [5]

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Compared with patients without diabetes, patients with diabetes have a 2fourfold higher risk of atherosclerotic cardiovascular diseases (ASCVD), including coronary artery disease, stroke, and peripheral artery disease [1]