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Step 4: Stool softeners and lubricants Docusate sodium (Colace) 100-200 mg twice daily Mineral oil 15-30 mL daily (oral or rectal) Stool softeners are the least effective option for GLP-1 constipation because the primary problem is motility, not stool hardness

Same goes for MOTS-C, which is currently in an ongoing Phase 2a clinical trial evaluating its effects on insulin sensitivity in adults with prediabetes and obesity

Through paracrine signaling from cells, GLP1 enhances insulin secretion, which in turn suppresses glucagon release from cells

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