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Briefly, cells were treated for 3 h with DMSO, 10 M cycloheximide (CHX
A major mechanism underlying APAP toxicity is cytochrome P450-catalyzed metabolic activation, which generates the reactive metabolite, NAPQ1 (Luo et al
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Simultaneously, MMP activity (the enzymes that digest matrix) gets regulated alongside their inhibitors (TIMPs)
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