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Comorbid MDD (PTSD + MDD) did not affect GSH in the ACC ( p = 0.623, n = 23 PTSD, n = 7 PTSD+MDD), nor in the DLPFC ( p = 0.457, n = 9 PTSD, n = 5 PTSD + MDD)

Similarly, cGMP-mediated pathways that promote long-term potentiation in the hippocampus may yield opposing effects in other circuits, depending on nitric oxide signaling and phosphatase activation