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Dangers of this hormone include potentially increasing the risk for some cancers and reducing life span
Full names for all the enzymes and substrates are given in Additional File 1
The discovery of BRAF mutations catalyzed the development of targeted therapies, significantly improving patient outcomes ( Figure 2 The approval of the BRAF inhibitor vemurafenib marked a significant advancement in the treatment of metastatic melanoma harboring BRAF V600 mutations ( In addition to their use in metastatic melanoma, BRAF and MEK inhibitors have also been explored in the adjuvant setting
