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doi: 10.1038/ki.2015.200 71 ZhangJPYanJXuJPangXHChenMSLiLet al

That design gives it a half life of roughly six days, which is what makes once weekly dosing possible in the first place

Serhan CN, Savill J

While currently no structure of SmTGRTrx complex exists, when aligning the available crystal structure of plasmodium TrxRTrx (PDB 4J56) with SmTGR one can infer where Trx (shown in orange) binds to SmTGR (Figure 1)