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5a), a pro-drug that combines sulphapyridine (an antibiotic) and 5-aminosalicylic (an anti-inflammatory agent) linked by an azo bridge, has huge therapeutic potential, but is, unfortunately, labile under physiological conditions (70% degradation by colonic bacteria via azo cleavage
The dual mechanism was confirmed at the cellular level, and the fragment showed no cross-reactivity with the growth hormone receptor (Ng & Borstein, 2003)
Quercetin reduced the formation of N -acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol in rats and isolated rat hepatocytes
A landmark study in Free Radical Biology and Medicine (2011) demonstrated that combining NAC (600 mg) with glycine (100 mg/kg/day) in elderly subjects restored GSH levels to those of young volunteers within just 2 weeks
To view a copy of this license, visit About this article Cite this article Tan, M., Yin, Y., Ma, X
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