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Riboflavin seems to function as a proteasome inhibitor 43,45 , resulting in the decreased degradation of the NF-B inhibitor, phosphorylated-inhibitor kappa (P-IB), thus preventing nuclear translocation of NF-B and subsequent pro-inflammatory gene activation 46
Acknowledgements The insights contained within this publication were generated in part by funding from the Gates Foundation to M.K.OB
A substantial proportion of these compounds are lipophilic in nature and exhibit extremely low solubility in the aqueous environment of the gastrointestinal tract
The reason for this mild profile is partly biological
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