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Main Body SGLT2 inhibitors consistently reduce HF hospitalization and cardiovascular death across the spectrum of ejection fraction, with relative risk reductions of approximately 3037% (Hazard ratio (HR) 0.630.70)
Insurance Claim Denials and Surprise Billing This is primarily a financial harm, not a clinical one, but financial surprise can lead patients to abruptly stop their GLP-1 agent without a supervised taper plan
Pediatr Clin North Am
Leone et al., 2019)
Since then, the Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity (SELECT) cardiovascular outcomes trial has shown that semaglutide 2.4 mg once weekly was associated with a significant 20% relative risk reduction in major cardiovascular adverse events compared with placebo [38]
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