However, we previously found that the human fetal liver may be uniquely vulnerable to lipotoxicity and oxidative injury due to lower expression of genes involved in fatty acid metabolism and peroxisome pathways and antioxidant enzymes compared to adult liver 31
Another study on high-fat diet-induced obese mice found that yerba mate reduced body fat, improved cholesterol levels, and regulated genes linked to metabolism
The delivery strategy used in this study, including a novel nanoformulation and an orobuccal administration, may be effective in improving the magnitude of absorption of other modulators of oxidative stress known to have limited bioavailability, such as resveratrol [22]
For patients with BMI 35+ or significant comorbidities (uncontrolled type 2 diabetes, severe obstructive sleep apnea), the health cost of waiting 6 weeks may outweigh the financial cost of paying out of pocket
Treating the entire skin at once would lead to a very long recovery with high risk for infection and complication (think intense chemical peels and fully ablative laser therapy)
