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For others, the benefits are more subtle and accumulate over several months

Reported side effects are typically mild and may include: Mild nausea (usually with oral forms) Temporary dizziness Gastrointestinal discomfort Injection site reactions (with injectable form) Most users report no significant side effects, making it an attractive option for those concerned about adverse reactions to traditional medications

Authors Kristina Hanspers , Christine Chichester , Egon Willighagen , and Denise Slenter Activity Discuss this pathway Check for ongoing discussions or start your own

The expression of a novel LOX-related gene, named LOXC, has been detected in cartilage in vivo , which modulates the formation of collagenous extracellular matrix ( de novo multiple musculoskeletal tissues (i.e., cartilage, meniscus, tendons, and ligaments) as important regenerative strategies, which is mainly mediated through mechanisms of hypoxia-induced enhanced PYR crosslinking and increased tensile properties of collagen-rich tissues (Makris et al., 2014)

In the subgroup of patients who were obese at the beginning of the trials, the weight changes were more substantial