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Legislators must decide if the long-term health benefits are worth the cost
The protocol: Reduce sulfonylurea dose by 50% when starting semaglutide Monitor blood glucose before meals and at bedtime for 2 weeks Many patients discontinue sulfonylureas entirely within 4 to 8 weeks as semaglutide reaches therapeutic levels The SUSTAIN-2 trial (Ahrn et al., Diabetes Care , 2018) showed that 41% of patients on sulfonylureas plus semaglutide experienced hypoglycemia, compared to 11% on semaglutide alone
Saxenda (liraglutide) Summary of Product Characteristics (EMA)
Consult your doctor if you experience persistent adverse reactions
The most common early adjustment is mild nausea during the first few weeks as your body gets used to the medication, and this typically eases significantly when the starting dose is kept low and increased gradually
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