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However, when food remains in the stomach longer, stomach acid has extended contact with the lower esophageal sphincter (LES), a muscle that normally prevents acid from backing up into the esophagus
However, some patients may still experience mild gastrointestinal effects
The number of patients included in the studies ranges from 1 (case report) to 440.089, with a median of 355 (IQR 1295) subjects
Patients frequently report improvements in sleep onset, sleep depth, and morning restfulness within 2-4 weeks
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