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Key mechanisms of action include: Delayed gastric emptying increasing meal satisfaction Reduced appetite through hypothalamic signaling Improved insulin sensitivity and glucose metabolism Decreased food reward and craving responses Enhanced satiety hormone production Blood sugar regulation occurs through enhanced insulin secretion when glucose levels rise
In hepatocellular carcinoma, the hypoxia-responsive PPARGC1A (peroxisome proliferator activated receptor gamma coactivator 1 alpha)/BAMBI (bone morphogenetic protein and activin membrane bound inhibitor)/ACSL5 (acyl-CoA synthetase long chain family member 5) pathway confers lenvatinib resistance [81]
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