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In clinical trials, tirzepatide has shown substantial reductions in HbA1c and body weight, with effects varying by dose and patient population
doi: 10.1038/bjp.2008.100 97 WebsterLRReisfieldGMDasguptaN
Both medications can cause nausea, especially in the first few weeks
The most studied and controversial target is SLC3A2, which can mediate the export of spermidine, spermine, and putrescine in colonic epithelial cells, as well as the extracellular release of the polyamine metabolic intermediate N1-acetylspermidine in liver cancer cells [290, 291]
Muscle loss (which starts in your 30s and accelerates in midlife) reduces your bodys ability to efficiently burn energy and maintain strength
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