Genistein administration induced Nrf2 enhancement by activation/phosphorylation of keap1, sirt1, MAPK-ERK1/2, PKC, and estrogen receptor in other cells or tissues, such as: hippocampal tissue, hypothalamic paraventricular nucleus, ovary, and Caco-2 cells [131, 135,136,137]
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(PubMed) Busse E, Zimmer G, Schopohl B, Kornhuber B
[13] Boiling or chlorine will kill microorganisms, but they will not remove lead or heavy metals