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Local concentration at the tendon drops to a fraction of what a direct knee injection delivers
As monotherapy , a multicentre, randomised, double-blind, placebo-controlled and active-controlled Phase 2 dose-finding trial enrolled 706 adults with overweight or obesity (without diabetes) to once-weekly subcutaneous cagrilintide across doses of 0.3 to 4.5 mg over 26 weeks
It is not FDA-approved and was flagged by the FDA as a safety risk for compounding
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