All estimates below assume bacteriostatic water and refrigeration at 2-8C
Reported side effects are generally mild and include temporary gastrointestinal discomfort, headaches during initial use, occasional fatigue as the body adjusts, and rare nausea, especially when taken without food
A 2022 review of 76 clinical trials noted participants who used GLP-1s specifically for weight loss, took a higher dose, and/or used the medication for more than 26 weeks were at a higher risk for gallbladder issues
For instance, a number of ongoing or completed trials are evaluating inhibitors of the PI3K-AKT-mTOR cascade, such as gedatolisib (NCT03065062) in advanced solid tumors, capivasertib (NCT04305496) in hormone receptor-positive breast cancer, and alpelisib (NCT02437318), which has shown efficacy in advanced breast cancer and is already approved for PIK3CA-mutated cases
It really helped me reduce heartburn that I struggled with for years