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Branched ubiquitin chains promote substrate degradation through the proteasome
As patients approach the BMI cut-off, we focus on: Planned dose reduction Managing appetite changes Supporting long-term weight stability Reinforcing sustainable habits without medication The goal is to protect health gains, not to prolong treatment unnecessarily
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That is why a diagnosis-first evaluation can be helpful
Clinicians are nonetheless advised to monitor patients on any hormonal therapy when initiating weight-loss treatments, given the potential for significant physiological changes with substantial weight loss
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