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implications for threshold and meaningful change estimation Helen Doll 1 , Michael DeRosa 2 , Shruti Dave 2 , Alyssa Bamer 3 1 Clinical Outcomes Solutions, Folkestone, UK, 2 Clinical Outcomes Solutions, Chicago, Illinois, USA, 3 Clinical Outcomes Solutions, Tucson, Arizona, USA Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :301.5 Aims Receiver operating characteristic (ROC) curve analysis is often used to estimate thresholds related to meaningful change or condition severity
Fainting or near-fainting: This is a strong signal to get evaluated
Similarly, SGLT2 inhibitors may be continued, although clinicians should monitor for dehydration or electrolyte imbalance
Do not use Zepbound if you are allergic to Tirzepatide
Studies have examined the possibility of therapeutically targeting EAT, and recent studies using sodium glucose cotransporter 2 inhibitors have shown potential in reducing EAT volume
